VetVine - Member Profile

Jeffrey Bryan

VetVine Member

First Name: Jeffrey
Last Name: Bryan
Profession: Veterinary Specialist
Degree(s) Earned: BS - Bachelor of Science, DVM - Doctor of Veterinary Medicine, MS - Master of Science, PhD - Doctor of Philosophy
Species Contact or Interest: Canine, Feline

Employment Information

Current employment status: Full Time
Employment: Academia

Academia:

Veterinary School: USA - University of Missouri

Employment Address

Hospital or Business Name: University of Missouri Veterinary Medical Teaching Hospital
Country: United States
State: Missouri
City: Columbia
Zip Code or Postal Code: 65211
Business Email: bryanjn@missouri.edu
Website: http://cvm.missouri.edu/oncology/bryan_j.html
Languages Spoken : English

Tell us more about you and your practice!

Brief Bio (include professional interests, hobbies, etc.): Dr. Jeffrey N. Bryan’s research focuses on comparative examination of cancers in companion animals to better understand cancers in all species. Bryan is an associate professor of veterinary oncology and director of the Comparative Oncology and Epigenetics Laboratory. His particular areas of interest are targeted imaging and therapy and epigenetics of cancer. Targeted imaging and therapy agents take advantage of particular properties of cancer to deliver an imaging or therapy payload to tumors. Bryan is leading research projects studying an immunotherapy agent targeted to the low-oxygen environment of cancer, an herbal derivative that targets iron in tumors, and a nanoparticle chemotherapy targeted to the lymphatic drainage of cancer. The agents under evaluation are destined for use in both dogs and humans to treat lymphomas as well as solid tumors like sarcomas, head and neck cancer, and breast cancer. Each of these trials is designed to develop an approach that is less toxic and more effective than our current cancer treatments.

Epigenetics is the study of mechanisms that change expression of genes critical to cell growth without changing the DNA sequence by mutation. DNA methylation can cause the complete silencing of genes that act as brakes on cell division without any mutation to the gene itself. Unlike mutations, which are permanent changes to the DNA, methylation can be reversed, and the gene can function again, putting the brakes back on cell growth. We are investigating epigenetic causes and contributions to animal cancers to assist in identifying the most biologically relevant changes in human cancers by comparison. Our program operates on the evidence that understanding disease in multiple species will help us progress more rapidly in treatment than if we look at one species at a time.

June 16, 2016 1:07 PM EDT

in the topic Hill's N/D for Cancer Patients in the forum Cancer

I am frustrated that many if not most dogs develop diarrhea or GI upset on ND. I have also not seen the benefit that was touted in the paper describing the diet. I hope other diets come to the market that will be more user-friendly.
June 16, 2016 1:07 PM EDT

in the topic Bernese Mountain Dogs and Lymphoma in the forum Cancer

This appears to be less of a problem than the histiocytic diseases. I have seen very few Berners with this disease. However, as a sporadic disease, any breed can get lymphoma.
June 16, 2016 1:06 PM EDT

in the topic L-Asparaginase in Lymphoma Protocols in the forum Cancer

I do. L-asparaginase is a very useful drug that is also an excellent rescue agent that does not suppress the bone marrow. I use it as indicated until the dog’s immune system reacts to it or it fails to work.
June 17, 2015 5:45 PM EDT

in the topic Toys - the dyes, latex, plastics and risk of cancer? in the forum Cancer

Yes, I think those are a concern. If you wouldn’t let your child chew on it, should you let your dog? I don’t give my dogs those things but I have no solid evidence that they are directly a risk.
June 17, 2015 5:41 PM EDT

in the topic Cancer and Genetics in Dogs in the forum Cancer

Yes, it appears so. Golden Retrievers have a 1 in 8 lifetime risk of cancer. Boxers are well known to get many cancers. Irish Wolfhounds are predisposed to osteosarcoma. There are many breeds, however, which do not appear to have higher than background cancer risks.

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