Hi Dr. Post-
After having our journal club discussion regarding the following articles, we came up with a few questions we wanted to ask you if you had more insight for us.
Regarding the article "Serial haemostatic monitoring of dogs with multicentric lymphoma" - Vet Comp Oncol. 2013 May 25. doi: 10.1111/vco.12041...
1. Have there been any other articles or unpublished research you are aware of regarding coagulation parameters in lymphoma dogs? If so, has that research also suggested that lymphoma dogs are hypercoagulable?
2. Can you explain a reason why this study found a correlation between higher hematocrit and weaker clots forming and vice-versa?
Regarding the article "Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs" - Res Vet Sci. 2012 Jun;92(3):444-50...
3. Are there any anti-angiogenic drugs available and/or effective against canine lymphoma? Are there any available against other types of tumors in dogs?
Thanks for your help,
Lynn Key
Lynn,
1. There have been a number of studies evaluating coagulation abnormalities in pets with cancer. Dr. Anne-Marie Kristensen from Denmark has published a few of these articles. Here is one of them http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342140/
2.the correlation of elevated HCT and weaker clots is a new finding and one that does need to be explained.
3. There are some antiangiogenic drugs out there- oral cyclophosphamide and NSAID combination being the most common. Given that angiogenesis is required for ALL tumors, effective antiangiogenic therapy may be effective for any tumor.
