<<  Canine Health Bytes On Demand - Canine Degenerative Myelopathy


Canine Degenerative Myelopathy:
From Gene Mutation Discovery to Clinical Trials
Joan R. Coates, DVM, MS, Diplomate ACVIM (Neurology)


Degenerative myelopathy (DM) is an inherited, adult-onset disease of the spinal cord causing progressive weakness and paralysis of the hind limbs and eventually all limbs. DM has clinical, histopathologic,
and genetic parallels to amyotrophic lateral sclerosis (ALS - Lou Gehrig's disease) in humans.

Mutations in an enzyme that converts superoxide to water and hydrogen peroxide, superoxide dismutase 1 (SOD1), have been linked to DM and human ALS. These discoveries have guided studies to further
understand the natural history, establish biomarkers, and initiate clinical trials for therapeutic strategies.

Join us in this webinar for a better understanding of DM including:

  • Genetic testing results as a risk factor for canine degenerative myelopathy
  • The neurologic progression in affected patients in terms of disease spread and changes in neuroanatomic localization
  • The pathophysiology of the mutated SOD1 protein and its consequences in the multifactorial pathogenesis of canine degenerative myelopathy
  • A platform of clinical trial designs and their potential applications in veterinary medicine

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NY State, NJVMA) by logging into VetVine (it's free to join)
and registering to attend / view the video on this page