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VetVine Client Care
Immunosuppressants And Kidney Disease
Internal Medicine
This question was asked during Session 2 of the Mastering IMHA program:
Question:
Do these advanced therapies you've discussed require dosing adjustments in chronic kidney disease patients?
Answer by John Loftus, PhD, DVM, DACVIM (SAIM, Nutrition):
Most of these drugs undergo hepatic metabolism so I generally wouldn’t. I do try to check to see if there is any need to dose reduce but the evidence in small animals is fairly sparse so we’re often extrapolating from people.