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Posted On Feb 02, 2026

Updated On Feb 05, 2026

Stomatitis And Dysbiosis - Could Probiotics Help?

Dentistry

This question was submitted related to the webinar titled Spotlight on Feline Chronic Stomatitis - Current Concepts and Future Directions:

Question:
Is dysbiosis a factor with this disease? Is there any evidence to show that probiotics can help in managing stomatitis in cats (FCGS)?

Answers provided by Boaz Arzi, DVM, DAVDC, DEVDC, FF-AVDC-OMFS and Rebecca Windsor, DVM, DACVIM (Neurology):

Dr. Arzi: There is ample evidence to support dysbiosis. No studies to my knowledge that support probiotic use in FCGS, but it wouldn't hurt as it has been shown to modulate the oral microbiome in healthy patients.

Dr. Windsor: Yes, studies have shown a link between oral dysbiosis and FCGS, and we are learning more and more how dysbiosis causes immune dysregulation in the mouth. Interestingly, one mechanism by which mesenchymal stromal / stem cells (MSCs) have been demonstrated to be effective for other conditions - including inflammatory bowel diseases in humans and cutaneous dysbiosis in humans - is by resetting the microbiome. I suspect that MSCs contribute to refractory stomatitis in this way as well.