This question was submitted related to the webinar titled Spotlight on Feline Chronic Stomatitis - Current Concepts and Future Directions:
Question:
Do you foresee that we will start to use mesenchymal stromal / stem cells (MSCs) in all cases of Feline Chronic Gingivostomatitis (FCGS) - not just refractory cases? Could this pre-empt us from having to do full-mouth extractions in affected cats?
Answers provided by Boaz Arzi, DVM, DAVDC, DEVDC, FF-AVDC-OMFS and Rebecca Windsor, DVM, DACVIM (Neurology):
Dr. Arzi: We (at UC Davis) just completed a project looking at full-mouth extraction with a single dose of MSCs administered at the end of the extraction and that data looks promising, but it is still under analysis. Extractions will always be necessary to some degree due to concurrent periodontitis and feline resorptive lesions.
Dr. Windsor: In a small study that Dr. Arzi published evaluating FCGS cats prior to extractions, MSCs appeared to be ineffective. Given the contribution of oral dysbiosis and viral positivity in many of these cats, as well as the fact that essentially all cats with FCGS also have varying degrees of periodontitis (mostly moderate-severe), removing the teeth likely removes some of the infectious load and chronic antigenic stimulation (which contributes to the aberrant immune response).
In Gallant's pivotal trial, 7 of 46 cats had partial-mouth rather than full-mouth extractions, and there was no significant difference in efficacy, but many dentists will recommend full-mouth extractions to potentially avoid two procedures. We ultimately plan to do a larger trial evaluating MSCs in cats prior to extraction. You can keep up with Gallant's clinical trials here.
×
