Not sure there is a “best” dose range. Though effective in humans for prevention of recurrent UTI, there is some very serious doubt about efficacy of this treatment for dogs with UTI. If there is ANY beneficial effect, it is to PREVENT new UTI from developing presumably by decreasing the ability of bacteria to adhere to the uroepithelium.
There is not much published about cranberry or cranberry extract supplementation for dogs - 2 abstracts in recent years.
Howell AB, Griffin DW and Whalen MO. Inhibition of P-fimbriated Escherichia coli adhesion in an innovational ex-vivo model in dogs receiving a bioactive cranberry tablet (Crananidin). J Vet Intern Med. 2010; 24: 678.
Smee N, Grauer GE and Schermerhorn T. Investigations into the effect of cranberry extract on bacterial adhesion to canine uroeptihelial cells J Vet Intern Med 2011; 25: 716-7.
The doses in mg/kg would depend on each specific cranberry compound as the concentration of PAC (proanthocyanidin) will be different in each. So it is not just the cranberry, but the amount of PAC provided by the particular cranberry product.
The Howell JVIM abstract reported a dose of about 1 mg/kg of Crananidan (Nutramax) in male dogs - at this dose urine did demonstrate some anti-adhesion properties (inhibition of agglutination of human red cells that normally occurs with p-fimbriated E. coli).
The Smee abstract studied cranberry extract (Vetoquinol 100 mg CE per tablet) in 5 female dogs and found that CE decreased ability of E. coli to adhere to canine uroepithelial cells in vitro.
David Senior did a Morris Animal Foundation study in 2003 and used Cranactin® at 500 mg per meter squared. At this dose to dogs, the urine did not inhibit bacterial adhesion to uroepithelium - not ever published just results in a final report to the Morris Animal Foundation.
There are NO studies that show cranberry extract is effective in reducing reinfections in dogs with naturally occurring UTI.
I don’t think I can give you a rational dose for CE in general, as the concentration of such varies widely by product. I am not aware of upper limit toxicity for cranberry extract and am not able to readily find papers showing high doses to be safe or toxic. A quick Google Scholar search fails to find much of anything about cranberry extract toxicity.
Not sure there is a “best” dose range. Though effective in humans for prevention of recurrent UTI, there is some very serious doubt about efficacy of this treatment for dogs with UTI. If there is ANY beneficial effect, it is to PREVENT new UTI from developing presumably by decreasing the ability of bacteria to adhere to the uroepithelium.
There is not much published about cranberry or cranberry extract supplementation for dogs - 2 abstracts in recent years.
Howell AB, Griffin DW and Whalen MO. Inhibition of P-fimbriated Escherichia coli adhesion in an innovational ex-vivo model in dogs receiving a bioactive cranberry tablet (Crananidin). J Vet Intern Med. 2010; 24: 678.
Smee N, Grauer GE and Schermerhorn T. Investigations into the effect of cranberry extract on bacterial adhesion to canine uroeptihelial cells J Vet Intern Med 2011; 25: 716-7.
The doses in mg/kg would depend on each specific cranberry compound as the concentration of PAC (proanthocyanidin) will be different in each. So it is not just the cranberry, but the amount of PAC provided by the particular cranberry product.
The Howell JVIM abstract reported a dose of about 1 mg/kg of Crananidan (Nutramax) in male dogs - at this dose urine did demonstrate some anti-adhesion properties (inhibition of agglutination of human red cells that normally occurs with p-fimbriated E. coli).
The Smee abstract studied cranberry extract (Vetoquinol 100 mg CE per tablet) in 5 female dogs and found that CE decreased ability of E. coli to adhere to canine uroepithelial cells in vitro.
David Senior did a Morris Animal Foundation study in 2003 and used Cranactin® at 500 mg per meter squared. At this dose to dogs, the urine did not inhibit bacterial adhesion to uroepithelium - not ever published just results in a final report to the Morris Animal Foundation.
There are NO studies that show cranberry extract is effective in reducing reinfections in dogs with naturally occurring UTI.
I don’t think I can give you a rational dose for CE in general, as the concentration of such varies widely by product. I am not aware of upper limit toxicity for cranberry extract and am not able to readily find papers showing high doses to be safe or toxic. A quick Google Scholar search fails to find much of anything about cranberry extract toxicity.
